化學與生命健康交叉研究中心

孔望清
時間:2020-04-23 14:37:43點擊量:

                             

孔望清

教授,博士生導師


郵箱:wqkong@whu.edu.cn

課題組主頁:http://wqkong.whu.edu.cn


研究方向

1)金屬有機化學:過渡金屬不對稱催化

2)自由基化學:發展新的策略實現自由基反應的立體選擇性控制

3)開展具有生物活性天然產物和藥物分子的高效合成研究


教育與研究經歷

2017.04-至今 武漢大學高等研究院,教授

2014.10-2017.03   瑞士洛桑聯邦理工大學 (EPFL),博士后,導師: Jieping Zhu

2011.09-2014.09   瑞士蘇黎世大學 (UZH),博士后,導師: Cristina Nevado

2006.09-2011.06   浙江大學,博士,導師:麻生明教授(中國科學院院士)


榮譽與獎勵

諾華制藥博士后獎學金(2012)

蘇黎世大學博士后基金(2011)

浙江省優秀畢業生(2011)

寶鋼優秀學生獎(2009)


Publications

22. Kuai Wang, Zhengtian Ding, Zhijun Zhou, and Wangqing Kong*. Ni-Catalyzed Enantioselective Reductive Diarylation of Activated Alkenes by Domino Cyclization/Cross-Coupling. J. Am. Chem. Soc., 2018, 140, 12364-12368.

21. Yuanyuan Ping, Yuxiu Li, Jieping Zhu*, Wangqing Kong*. Construction of Quaternary Stereocenters by PalladiumCatalyzed CarbopalladationInitiated Cascade Reactions. Angew. Chem. Int. Ed. 2018, DOI: 10.1002/anie.201806088.

20. Yuxiu Li, Kuai Wang, Yuanyuan Ping, Yifan Wang, and Wangqing Kong*. Nickel-Catalyzed Domino Heck Cyclization/Suzuki Coupling for the Synthesis of 3,3-Disubstituted Oxindoles. Org. Lett. 2018, 20, 921?924 (Highlighted by Synfacts, 2018, 14(4), 410)

19. Kuai Wang, Wangqing Kong*. Recent Advances in Transition Metal Catalyzed Asymmetric Radical Reactions. Chin. J. Chem. 2018, 36, 247-256. (Cover Story)

Before independent work:

18. Wangqing Kong, Qian Wang, Jieping Zhu*. Water as hydride source in palladium-catalyzed enantioselective reductive Heck reaction. Angew. Chem. Int. Ed. 2017, 56, 3987-3991. (Chosen by the Editors as a “Hot Paper”) (Highlighted by Synfacts, 2017, 13(5), 495) (Highly Cited Paper)

17. Wangqing Kong, Qian Wang, Jieping Zhu*. Switchable synthesis of diversely functionalized oxindoles enabled by migratory insertion of isocyanide to a transient σ-alkylpalladium(II) complex. Angew. Chem. Int. Ed. 2016, 55, 9714-9718.

16. Wangqing Kong, Qian Wang, Jieping Zhu*. Palladium-catalyzed enantioselective domino heck/intermolecular C-H bond functionalization: Development and application to the synthesis of (+)-esermethole. J. Am. Chem. Soc. 2015, 137, 16028-16031. (Highlighted by Synfacts, 2016, 12(3), 274.)

15. Wangqing Kong, Noelia Fuentes, Andres García-Domínguez, Estíbaliz Merino, Cristina Nevado*. Stereoselective synthesis of highly functionalized indanes and dibenzocycloheptadienes via complex radical cascades. Angew. Chem. Int. Ed. 2015, 54, 2487-2491.

14. Noelia Fuentes, Wangqing Kong, Luis Fernández-Sánchez, Estíbaliz Merino, Cristina Nevado*. Cyclization cascades via N-amidyl radicals toward highly functionalized heterocyclic scaffolds. J. Am. Chem. Soc. 2015, 137, 964-973. (Highly Cited Paper)

13. Wangqing Kong, Estíbaliz Merino, Cristina Nevado*. Arylphosphonylation and arylazidation of activated alkenes. Angew. Chem. Int. Ed. 2014, 53, 5078-5082. (Chosen by the Editors as a “Hot Paper”) (Highly Cited Paper)

12. Wangqing Kong, Estíbaliz Merino, Cristina Nevado*. Divergent reaction mechanism in the aminofluorination of alkenes. CHIMIA International Journal for Chemistry, 2014, 68, 430-435.

11. Wangqing Kong, Maria Casimiro, Noelia Fuentes, Estíbaliz Merino, Cristina Nevado*. Metal-free aryltrifluoromethylation of activated alkenes. Angew. Chem. Int. Ed. 2013, 52, 13086-13090. (Highly Cited Paper)

10. Wangqing Kong, Maria Casimiro, Estibaliz Merino, Cristina Nevado*. Copper-catalyzed 1-pot trifluoromethylation/arylmigration/desulfonylation and Csp2-N bond formation of conjugated tosyl amides. J. Am. Chem. Soc. 2013, 135, 14480-14483. (Highly Cited Paper)

9. Wangqing Kong, Pascal Feige, Teresa de Haro, Cristina Nevado*. Regio- and enantioselective aminofluorination of alkenes. Angew. Chem. Int. Ed. 2013, 52, 2469-2473. (Highlighted by Synfacts 2013, 9 (4), 371 and Organic Chemistry Portal 2014, March 17.) (Highly Cited Paper)

8. Wangqing Kong, Youai Qiu, Xue Zhang, Chunling Fu, Shengming Ma*. Exclusive 1,2-aryl shift in Platinum(II) chloride-catalyzed cyclization of 1-(indol-2-yl)-2,3-allenols. Adv. Synth. Catal. 2012, 354, 2339-2347.

7. Wangqing Kong, Chunling Fu, Shengming Ma*. Efficient synthesis of carbazoles via PtCl2-catalyzed RT cyclization of 1-(indol-2-yl)-2,3-allenols: scope and mechanism. Org. Biomol. Chem. 2012, 10, 2164-2173.

6. Wangqing Kong, Chunling Fu, Shengming Ma*. General Au-catalyzed benzannulation towards naturally occurring carbazole alkaloids from methoxypropadiene. Chem. Eur. J. 2011, 17, 13134-13137.

5. Wangqing Kong, Binjie Guo, Chunling Fu, Shengming Ma*. An efficient approach to 2-bromoalken-3-ols by regioselective bromohydroxylation reaction of simple allenes with NBS. Eur. J. Org. Chem. 2011, 2278-2285.

4. Wangqing Kong, Chunling Fu, Shengming Ma*. An efficient synthesis of polysubstituted naphthalene derivatives by gold-catalyzed cyclization of 1-arylalka-2,3-dienyl acetates. Eur. J. Org. Chem. 2010, 6545-6555.(Cover Story)

3. Wangqing Kong, Jie Cui, Yihua Yu, Guofei Chen, Chunling Fu, Shengming Ma*. PtCl4-catalyzed cyclization reaction of β-allenols in the presence of indole. Org. Lett. 2009, 11, 1213-1216.

2. Wangqing Kong, Chunling Fu, Shengming Ma*. An efficient synthesis of carbazoles from PtCl2-catalyzed cyclization of 1-(indol-2-yl)-2,3-allenols. Chem. Commun. 2009, 4572–4574.

1. Wangqing Kong, Chunling Fu, Shengming Ma*. Indium and zinc-mediated Barbier-type addition reaction of 2,3-allenals with allyl bromide: an efficient synthesis of 1,5,6-alkatrien-4-ols. Org. Biomol. Chem. 2008, 6, 4587–4592.


專利

1.一種合成咔唑類化合物的方法,專利號:ZL 200910099482.X

2.一種合成咔唑類生物堿 Siamenol 的方法,專利號:ZL 201110283659.9

3.一種合成天然咔唑類生物堿的制備方法,專利號:ZL 201110283147.2

4.一種合成咔唑類化合物的方法,專利號:ZL 201210516430.X

 

課題組招賢納才

博士后

  薪酬待遇:工資及福利待遇根據武漢大學相關規定從優考慮(五險一金,解決戶口和子女入學等問題);并根據工作業績額外發放津貼(預計年薪25-30萬元,具體薪資待遇面議);可作為負責人申請博后基金、國家青年基金、和湖北省相關基金。博士后期間特別優秀者可協助申請武漢大學正式教師(非獨立成組)。

職位要求:

1)有機化學博士,有寫作和發表英文科技論文經歷。

2)有團隊精神,工作踏實,有責任感,易溝通。

3)有金屬有機化學(特別是過渡金屬不對稱催化)或自由基化學研究經歷者優先考慮。

請發送個人簡歷、主要研究成果等相關資料到:wqkong@whu.edu.cn

研究助理2-3

薪酬待遇:將提供具有競爭力的薪酬待遇,并根據工作業績額外發放津貼,可優先報考碩士或者博士研究生。

職位要求:

1)本科或碩士學位,化學相關專業,熟悉常規有機化學實驗技術和操作。

2)工作踏實,有責任感,具有良好的溝通能力和合作精神。

3)英語良好,能獨立閱讀英文文獻。

請發送個人簡歷及其他能證明本人能力的相關資料到:wqkong@whu.edu.cn

研究生

  歡迎全國的優秀學子報考本小組的博士或碩士研究生。要求專業基礎扎實,工作踏實,有團隊精神,具有良好的溝通能力。我們將提供具有競爭力的待遇,并根據工作業績額外發放津貼。有意者請直接郵件聯系wqkong@whu.edu.cn



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